Protocol for when you should use an out-of-office message will vary by job and industry, but generally, you should set an OOO message when you’ll be out for two or more days.
Former coworker: “I am out of the country from X until Y. Please do not email me during this time as last time I came back to about 250, and reading them all takes up a lot of the time I have left before I retire.” Some people thought that was funny. The director who received that in response to an all staff communication? Not so much. Coworker got a talking to by his manager when he got back to the UK.

Everything’s a little off-kilter as we continue to contend with the COVID-19 pandemic. It’s hard to step away from work when the “office” is the dining room table you can see from your couch. It feels a little strange to take PTO when travel and boisterous family gatherings seem like a distant memory. You might be working odd hours so you can juggle childcare and other responsibilities. Or maybe your full-time job became a part-time one (or an on-hold one) as a result of the economic downturn that hit along with the coronavirus.
Then there was the occasional one who would do what Alison mentioned with the sickness excuses, and create a tale that read like a police report: “I must miss my deadline because, on the night of August 12, my 45-year-old sister was alone in her house when an intruder entered. He was a 6’1″ caucasian male wearing a black balaclava and carrying a candlestick. As my sister approached him, with the dog barking around her heels, she heard a distant car crash which led her to have a fatal … etc.” (This is not an actual excuse I received, just similar in detail to some of those that were submitted.) These ones I was pretty sure were a writing exercise, requiring time and effort that could have been put to better use on the actual assignment they had been given.