Point out trends you’ve seen in your friend over and months and years, such as improvements in how he or she relates to others. If you know it’s a struggle for your friend to keep her cool under deadlines at work, you could tell her, “I’ve noticed how patient you are with your office coworkers lately.”
This is too much. If someone said something like “I’m at the beach until Jan 5!” instead of “I’m out of the office until Jan 5,” I’d appreciate the slight personal touch. But don’t share too much. We just need to know that you’re not gonna answer our email for a while.

We have some field staff who have out of office replies set up for when they do fieldwork. On one hand it’s nice I guess, but on the other hand, they aren’t dealing with urgent matters only they can handle (they don’t manage projects or deal with clients), so it seems a bit unnecessary? No one has been disciplined for not responding to an email the same day. But maybe I’m just a crabby Gen-Xer, and a client can stand to wait a few hours or until the next day to get an answer from me.
This is what I’ve seen most often in my career. Problem is, the contact is almost always the admin. I’m the admin. Everyone’s idea of assistance is different. Often, I didn’t have the knowledge about the issue in order to be of any assistance. I wound up spending more time running around looking for answers than actually working on what was on my own plate. It’s exhausting. Otherwise known as “please don’t call us for unicorn problems when we handle llamas. Literally, we can’t do anything for unicorn problems.”