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An out-of-office message is an effective way to inform people why you are not responding to their calls or messages and when they can expect a response. This information saves them from getting frustrated and avoids any negative impression from the inability to respond. If you have long-term relationships with your customers, such an auto-response system is highly significant as it avoids any inconvenience.

Let’s say you’re a CFO headed to Cancun for your annual vacation. You write an OOO message that contains: The dates of your departure and return Contact information for a colleague that will be available in your absence Some details about your destination
I used to work with someone who had a message telling people she only checked her email twice a day. You pretty much needed to call her if you needed anything outside of those times. (She worked in a remote office.) I think she had read one of those books on efficiency that recommended scheduled email time. But there were problems with this: 4. My department often had to email attachments or text to illustrate our questions/concerns. And we were on deadlines. Reading a page of text over the phone was not an efficient use of anyone’s time 5. She did outreach & was often out of the office on site visits, trainings, or travel to these places, but never ever set her OOO for these, because she was “working.” However, she was effectively not available to read emails from other staff until after hours on those days.