As a part time person, I now put an OOO on my non-work days since I was getting snarky comments about slow response times. (People don’t realize I’m part time and my position is not suited at all to it.) Dude, I didn’t respond because I don’t get paid to work on Fridays.
You’ll have options to set a “first day” and “last day,” or just “first day.” If you want things truly automated, picking a “last day” will trigger the autoresponder to automatically turn itself off the day after the selected date. Of course, in those instances when you’re unsure of your exact return date, it’s best to leave this open-ended. The “out of office” subject line is much less creative and scientific than say, a cold email subject line or a marketing email subject line. More often than not, they’re very plain and simple, like the following:

Use your absence as an opportunity to show off to customers and peak their interest in your content. Sending an out-of-office email is a good way to provide clients with more details about your business. Offer a link to an interesting online resource that your company has developed, like a blog post. This way, recipients are made aware of which lines of business your company are actively engaged in.
Set a minimum delay for auto-responses. For example, if you set a minimum delay of 1, the eDesk will send the OOO template 1 minute after receiving the customer’s message. If you don’t set a minimum delay, eDesk will auto-respond immediately upon receipt of a message.