Being left out is an emotional drama that unfolds in three acts: discovery, distress, and, if you can get there, detachment. These psychological rhythms prevail whether you are reeling from the whispers of a group of girls at recess or excluded from a bridge game in your assisted-living home.
Who says an autoresponder needs to be impersonal? You can use your OOO message to continue building a relationship with present and potential customers by showing off the knowledge and products you have to offer. You can include a case study, a downloadable to your latest report, or a link to an excellent blog post you published. Not only does this further your credibility, but it also allays the feelings of frustration customers might feel while not being able to reach you.

Setting an auto-response email is probably not the first thing on our mind before we jet off on holiday. But if we don’t do it, we risk eroding the trust between ourselves and our customers. It’s important to remember that response time is a non-verbal sign that shows clients and business partners how responsible and professional a company is.
I include my boss because I have different backups for five or six different parts of my job, and my boss is more likely to know the nuances of which one is the appropriate contact than the person sending the email, so it’s more likely to get to the right person if she redirects than if the emailer tries to guess which one of the six contacts I listed is the one who can solve their problem. (My specialty is the “other things as requested” section of my job description; I’m sort of a jack of all trades around here. :) )