I work in a culture where even when you say you won’t have access to email, you are expected to be checking. I include this only on the internal auto-response, so that the people in my company know that when I say I won’t have access to email (which is also explained in the email), I mean it. Nothing else seems to work.
Since I’m out of the office for the Thanksgiving weekend, I’ll respond to your email with a list of 10 things I’m thankful for: Copiers that collate Co-workers that brew more coffee when they empty the pot Donuts on Mondays AND Fridays When IT surprised me with a new laptop AND remembered to transfer my files When You-Know-Who died at the end of book 7 Dry-erase boards that actually erase The brave soul who cleaned out the refrigerator When I’m early to an all-staff meeting and score a table near the door HR finally sent a memo telling people to STOP clipping their nails at their desk OOO autoresponders

In this image, you're letting people know you're OOO with a "Missing" notice on a milk carton. Genius. Just be careful — this sort of autoresponder is best for internal emails, not for autoresponders that get sent to prospects and clients.
We had someone at my old job whose auto-reply stated that they were at a “White Privilege Conference”. Granted, the conference was about dismantling White Privilege, but to someone outside our work who didn’t know that, I imagine that got quite the reaction!