Whatever you decide before heading out for that much-needed time off, it’s imperative that you set up an out of office reply. Your customers and co-workers don’t get that same pause button as you do. That’s why you should inform everyone that needs to know about your time off.
What we need in our work communication is not more professional politeness or less formal, chat-based messaging applications like Slack. We need honesty. The problem is that we’ve conditioned ourselves to see honesty as self-indulgent or disrespectful. I’d argue the opposite is true. Honesty, even if it’s a bit more inconvenient for all parties in the moment, pays dividends later. It builds trust. When my partner Anne Helen Petersen and I were interviewing people for our forthcoming book on remote work, a frequent lament from both middle managers and workers was that they didn’t feel like they knew how to succeed in their jobs; that they were guessing what their superiors and coworkers wanted and, even when they asked, they didn’t quite trust the responses they got back.

The main goal of an auto-respond email is to ensure clarity of communication expectations and offer appropriate alternatives.
A retired small town newspaper guy once told me about the first time the publisher went on vacation and left him in charge (this would have been in the 80s). The publisher told him “Don’t call me unless the building burns down, and even then, don’t call me until the fire is out.” Good example of management setting vacation expectations.