I ran a nonprofit organization staffed entirely be volunteers (I was one). After one too many people incensed that we did not follow up to their emails within two hours, we had to include an OOO message that said we were a volunteer organization, and any request may take up to two weeks to process. Please email again if you have not heard from us by then.
It makes a positive difference when you create auto reply messages that adhere to the basic elements of personalized messages followed with greetings.

Click the Out Of Office tab, and in the Date & Time Conditions - One-off section, click + Add date range. Set a date range by clicking the date fields and then selecting a start and end date from the calendars. Set a start/finish time for the dates by clicking the time fields and then dragging the sliders horizontally to select the Hour and Minute. If you want your autoresponse to look like a human response, you can tell eDesk to delay sending this template for x minutes. Pro-tip: You can use this to prevent Amazon from detecting your message as an auto-response. Set Frequency if you want to prevent eDesk from auto-responding with the same template to every message about the same ticket. For OOO templates, it is common practice to select Autoreply every single incoming message but you can also select a frequency, for example, once every 6 hours. If you want to tell eDesk NOT to auto-respond with this template to messages from certain email addresses, enter them into the Exclude field, for example, [email protected], [email protected]. You can also exclude all email addresses from a certain domain by entering *@domain.com, for example, *@xsellco.com Tick this if you want to include the signature for the channel in the template.
Anybody that might need me that quickly should have access to my calendar and can see I’m in a meeting. Anybody that can’t see my calendar shouldn’t expect a reply in an hour unless I’d said I’d be available or something.