250? That could easily be only 2-3 days of emails. You can’t declare “email bankruptcy” for only a few days worth of emails. I average about 200 a day, so if I was on vaca and came back to only 250 mails, I would be putting in a ticket with IT, thinking something was broken.
3. Suggest Reading the Documentation. This is the office closed for holiday template that our support team uses. If you have an extensive documentation published on your site, you can recommend users to read the documentation while you get back to your users.

My parents ran a furniture refinishing shop when I was in school. There are workshops and conferences for this trade. I attended a private high school that was primarily a boarding school. Once, when my parents needed to attend a middle-of-the-week event, they arranged for me to stay overnight in the school dorms. Upon being asked by the house mother where my parents were, I said they was at a stripping convention.
If you don’t clearly state the dates on which you will be disconnected from work, your office co-workers and clients will most likely send you multiple emails, clogging your inbox. That will make it quite difficult for you to catch up when you get back. Also, if you don’t include the name and contact information in your outgoing message for the co-workers who can help in your absence, your well-deserved and pleasant vacation time could get in the way of specific projects in the company.