When we set an out-of-office, we don’t immediately think of lead generation. However, it is a good opportunity to this end. For instance, you could encourage attendance for a webinar or future event, suggest sign-ups for online courses, give links to book downloads, or point recipients in the direction of any other product or service you are pushing. As well as informing the recipient of your unavailability, you are encouraging them to act.
Yeah, announcing you were going to delete emails unread and expecting the sender to resend when you return would NEVER fly in my office. I’d get executive complaints about that, especially if it went to a client or outside party – if a client can’t reach you, they will reach out to someone else who may not work at your organization and you lose business. I feel like this delete-it-all philosophy would only work for an entirely internal role where timelines are more relaxed, and even then, I feel it’s a bit unprofessional to foist your own catch-up work onto others, especially if they’ve been backfilling for you while you were OOO.

I have been out the office working from home for more than a year now. After a few weeks of remotely checking VM (and sometimes forgetting for days) I simply changed my phone setting so you cannot leave a message. I have not regretted since. On very few occasions people have clicked 0 and gone to reception. Reception can IM me and ill call or email the person back if I want or they can give them my email. Everyone else either emails me or if they already have it call my cell. Internal people never call my phone they use IM or video chat. No one internally has had an issue with this and this eliminates the whole hey call me back to spend 30 minutes talking about something that I could have answered in 2 minutes in an email.
While the sender waits for your response to their email, take the sting out of your absence by involving them in a holiday survey, like the one below.