Giving the option to contact an email address containing “interruptyourvacation” provides two things — 1) A dose of humor, and 2) discouragement from actually doing what the name suggests. Plus, he prefaces it with a request for empathy, by explaining that he promised quality time to his family.
In 2013, researcher danah boyd wrote a LinkedIn blog post advocating for the nuclear option which was framed in the piece as an “email sabbatical.” Coming back to an empty inbox after a vacation is should be a break from the insanity, not a procrastination of it,” boyd wrote of the decision to send everything to the trash.

Hahahahaha, reminds me of the time the entire giant department (hundreds of people) had to sit through a SLIDE SHOW of a higher up’s trip to Europe, in person. They sent a survey afterwards–thankfully anonymous–and I said it was extremely inappropriate to make us sit through his holiday snaps when most of us can’t go on vacation at all and it was supposed to be a WORK meeting.
The majority of your out-of-office emails will go to recipients with whom you communicate regularly. If you are sure that there’s a certain level of familiarity with all of the people that get your auto-reply messages, consider writing something about yourself, a funny note, or a joke. That allows them to develop a more personal relationship with you.