You just have to be very certain of your audience if you’re going to use an email with humor. It has to be the right tone, and it has to be right for your business and your clientele.
Hollywood star turned gin distiller Ryan Reynolds showed last summer how the OOO can become a marketing tool. “Thank you for your email and interest in Aviation American Gin! I’m away from my desk at the moment but will respond the moment they give me a desk,” began his first attempt. A few months later, along came another: “This is only my 2nd OUT OF OFFICE REPLY. From what I’m told, it should be short, sweet and NEVER overly personal or emotional.” After TV host Jimmy Fallon asked him to read one out on The Tonight Show, the resulting influx – around 20,000 emails in a single day – to [email protected] melted the small brand’s servers. Fortunately, it also reportedly piqued the interest of retailers and restaurants, keen to start carrying the tipple.

An out of office message is a compact text that conveys the most important facts: How long you’ll be unreachable, when your contacts can expect an answer, (optionally) the reason for the absence, and, if necessary, a personal note. A referral to another email address, e.g. to one of your colleagues, is often helpful or even necessary.
A relatively unprofessional one — like mine, for instance — does the opposite: It encourages prospects, recruiters, and potential connections to run in the other direction.