The auto-reply only replies ONCE to each email account, the first time they send. If someone sends you multiple messages, they will not get multiple replies back. This is a useful feature because it prevents your account from flooding a mailing list with replies or from filling your email inbox with automatic rejections from "do not reply" accounts.
I used to work with someone who had a message telling people she only checked her email twice a day. You pretty much needed to call her if you needed anything outside of those times. (She worked in a remote office.) I think she had read one of those books on efficiency that recommended scheduled email time. But there were problems with this: 4. My department often had to email attachments or text to illustrate our questions/concerns. And we were on deadlines. Reading a page of text over the phone was not an efficient use of anyone’s time 5. She did outreach & was often out of the office on site visits, trainings, or travel to these places, but never ever set her OOO for these, because she was “working.” However, she was effectively not available to read emails from other staff until after hours on those days.

One aspect of preparing to take off work for a holiday involves setting up your out of office email reply. By reviewing some key examples of out of office messages, you can craft your own before your holiday time off. In this article, we define holiday …
During winter break, certain essential services must still be provided on our campuses, such as hospital operations at UTMC, approved research activities and public safety. Therefore, winter break does not include UTMC employees nor certain required positions, which might vary annually depending on need.