Front makes it easy to save vacation responders and turn them on and off. If you're not on Front (yet!) here's how to save one in Gmail or Outlook. Then just copy your message into your vacation responder, rest assured your emails will get a response, and hit that glorious "Sign out" button.
In spite of your best efforts to notify people ahead of time, not everyone will get the notification that you're going to be shut down. Make sure that you: Post signs about the shutdown and when you will be back Change your voicemail message and have a plan for what to do if your voicemail is full: will it notify you? Is there an alternate number to call? Put together an "out of office" email that lets people who attempt to contact you know when you will be back Make sure you have a call tree for emergencies, and that everyone knows who he or she will be responsible for calling in the event of an emergency

Not exactly a neutral audience, though. A number of people following the account, if not most, will be following because they share the same sense of humor. Likewise people @ed by friends.
*using a professional email marketing solution you can personalize your emails by using your customers’ first name as well as other personalized tokens containing info you have about your customers